Overmethylation vs. Undermethylation



Methylation is a balancing act and it is possible to be out of balance and fall on either side of the optimal line. If you produce too many methyl groups (1 carbon and 3 hydrogen) or too few methyl groups, your body will have an imbalance in its methylation cycles and symptoms of these breakdowns will start to show in your health. Studies have shown that the symptoms from over-methylation differ from those of under-methylation.


Over-Methylation Symptoms and Traits

Personality traits of overmethylation often include those who are the creative, artistic and sensitive types. These people tend to look for jobs in the music and arts arena.

  • High anxiety or panic tendencies
  • Paranoid Schizoprenia (studies have shown higher levels of methylation in PS patients)
  • Depression
  • Sleep Disorders
  • Heavy body hair
  • Artistic or musical ability
  • Copper overload
  • Low libido
  • Tendency to be overweight
  • Belief that everyone thinks ill of them
  • History of eczema
  • Hyperactivity
  • Low motivation
  • Food sensitivities
  • Dry skin, eyes and/or mouth
  • Obsessions without compulsions
  • High pain threshold

Under-Methylation Symptoms and Traits

Personality traits of undermethlyation often include those who are extremely competitive, perfectionists and high achievers. They tend to be scientists, doctors, lawyers professional athletes or corporate professionals.

  • History of perfectionism
  • Competitive
  • Calm demeanor, but high inner tension
  • Frequent headaches
  • High libido
  • Slenderness
  • Delusions (thought disorder)
  • Very strong willed
  • Obsessions with compulsions
  • Poor concentration
  • Phobias
  • Self motivated
  • Addictions
  • Low pain threshold
  • High fluidity (tears, saliva, etc…)
  • Is it also of note that under-methylation in mother’s leads to a greater risk of autism in the baby. If you are planning on getting pregnancy, a program to balance your methylation is highly recommended.


The good news is there are ways to balance these methylation imbalances and restore health in your body.

Overmethylation Supplements

  • Zinc
  • Vitamin B12
  • Vitamin B6
  • Vitamin E
  • Vitamin C
  • Omega-3 fatty acids
  • Folate

Undermethylation Supplements

  • SAMe
  • Omega-3 fatty acids
  • Magnesium
  • Calcium
  • Methionine
  • Vitamin C
  • Vitamin B6

Soli’s Functional Methylation Analysis

If you are interested in a comprehensive approach to methylation balancing, please review our services to see if they may be a good fit for your wellness journey.


Any recommendations/consultations with respect to nutritional health, diet, supplementation or detoxification is done exclusively for educational and information purposes and is for non-diagnostic purposes and general guidelines only. The determination to take or withdraw from any medical intervention resides within the legislative authority of physicians, nurses and nurse practitioners. We support the distribution of current research and information relating to all topics and likewise encourage patients and clients to make informed health care decisions having researched and understood all balanced and accurate information to which those decisions pertain. In every case, please consult your medical physician regarding any changes you make to your medical regimen, as doing so without consultation or supervision by a qualified practitioner may be dangerous.



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